CASE REPORT: SEQUENTIAL COMBINATION TARGETED THERAPY WITH TYPE I AND II MET INHIBITORS IN A METASTATIC EGFR-MUTATED, MET-AMPLIFIED NSCLC PATIENT WITH ACQUIRED MET Y1230H MUTATION

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard of care for advanced non-small-cell lung cancer (NSCLC) patients.However, most patients will eventually develop resistance.For EGFR-TKI resistance mediated by MET amplification, the combination of EGFR and MET TKIs has shown promising results in early clinica

Thyroid dyshormonogenesis is a leading cause of congenital hypothyroidism, a highly prevalent but treatable condition.Thyroid hormone (TH) synthesis is dependent on the formation of reactive oxygen species (ROS).In humans, the primary sources for ROS production during thyroid hormone synthesis are the NADPH oxidases DUOX1 and DUOX2.Indeed, mutation

Keratoconus is a progressive ectatic disorder of the cornea which often presents with fluctuating refraction and high irregular astigmatism.Correcting the vision of these patients is often a challenge because glasses are unable to correct the irregular astigmatism and regular contact lenses may not fit them very well.Topography-guided custom ablati

The article substantiates recommendations on improving the tax mechanism for regulating the click here activities of public organizations as a special group of tax payers, the problems in the activities of public organizations in the Russian Federation with the use of economic and statistical, etc.are investigated methods of scientific cognition.Th

The aim of this paper is to point out the necessity of introducing additional levels of quality control over financial reporting in the Republic of Serbia.The existing levels of control (internal, external and state audit, and tax control) are not click here sufficient to prevent and detect fraud in the operations of companies.Numerous cases of fra